Peer Reviewed Papers

A significant body of literature exists supporting the safety and effectiveness of SpaceOAR hydrogel.

Peer-Reviewed Papers

Absorbable Hydrogel Spacer Use in Prostate Radiotherapy: A Comprehensive Review of Phase 3 Clinical Trial Published Data

Lawrence Karsh, MD, Eric Gross, Christopher M. Pieczonka, Philip J. Aliotta, Christopher J. Skomra, Lee E. Ponsky, Peter T. Nieh, Misop Han, Daniel A. Hamstra, Neal D. Shore, doi.org/10.1016/j.urology.2017.11.016

Hydrogel spacer distribution within the perirectal space in patients undergoing radiotherapy for prostate cancer: Impact of spacer symmetry on rectal dose reduction and the clinical consequences of hydrogel infiltration into the rectal wall

Fischer-Valuck BW, Chundury A, Gay H, Bosch W, Michalski J.
Pract Radiat Oncol. 2016 Oct 17. pii: S1879-8500(16)30222-3. doi: 10.1016/j.prro.2016.10.004. [Epub ahead of print]

SpaceOAR Hydrogel in Dose-escalated Prostate Cancer Radiotherapy: Rectal Dosimetry and Late Toxicity

Whalley, G. Hruby, F. Alfieri, A. Kneebone, T. Eade. Clin Oncol (R Coll Radiol). 2016 Oct;28(10):Epub 2016 Jun 11

Applying radiobiological plan ranking methodology to VMAT prostate SBRT

Stavrev P, et al. Physica Medica on line April 2016 article in press

SBRT for prostate cancer: Challenges and features from a physicist prospective

Mancosu P, et al. Physica Medica 2016 Apr 6. pii: S1120-1797(16)30006-0. doi: 10.1016/j.ejmp.2016.03.011. [Epub ahead of print]

Decision analysis model evaluating the cost of a temporary hydrogel rectal spacer before prostate radiation therapy to reduce the incidence of rectal complications

Hutchinson R, Sundaram V, Folkert M, Lotan Y. Urol Oncol. 2016 Mar 30. pii: S1078-1439(16)00080-6. doi: 10.1016/j.urolonc.2016.02.024. [Epub ahead of print] PMID: 27038698

Current role of spacers for prostate cancer radiotherapy

Pinkawa M, et al. World J Clin Oncol 2015 December 10; 6(6): 189-193

Comparison of two different rectal spacers in prostate cancer external beam radiotherapy in terms of rectal sparing and volume consistency.

Wolf F., et al. Radiother Oncol. 2015 Aug;116(2):221-5. doi: 10.1016/j.radonc.2015.07.027. Epub 2015 Jul 28.

Spacer application for prostate cancer radiation therapy

Pinkawa M, Et al. Future Oncol. (2014) 10(5), 851–864

Retreatment for prostate cancer with stereotactic body radiation therapy (SBRT): Feasible or foolhardy?

Arcangelia S. et al. Rep Pract Oncol Radiother. 2015 Nov-Dec;20(6):425-9. Epub 2014 Sep 10

Hydrogel Spacing for Radiotherapy of Prostate Cancer: A Review of the Literature

Mahal BA, et al. Urology Practice Volume 1, Issue 2, Pages 79–85, July 2014

Spacer Application for Prostate Cancer Radiation Therapy

Pinkawa M. Future Oncol. 2014 April 10

Fiducial Markers and Spacers in Prostate Radiotherapy: Current Applications

Ng M, et al. BJU Int. 2014 Mar;113 Suppl 2:13-20

Quality of life after intensity-modulated radiotherapy for prostate cancer with a hydrogel spacer : Matched-pair analysis

Pinkawa M, et al. Strahlenther Onkol. 2012 Oct;188(10):917-925. Epub 2012 Aug 31

Application of a spacer gel to optimize three-dimensional conformal and intensity modulated radiotherapy for prostate cancer

Pinkawa M, et al. Radiotherapy & Oncology. 2011 Sep;100(3):436-41. Epub 2011 Sep 29

Human Collagen Injections to Reduce Rectal Dose During Radiotherapy

Noyes WR, et al. Int J Radiat Oncol Biol Phys. 2011 Apr 22.

Cross-Linked Hyaluronan Gel Reduces the Acute Rectal Toxicity of Radiotherapy for Prostate Cancer

Wilder RB, et al. Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):824-30.

Effects of prostate-rectum separation on rectal dose from external beam radiotherapy

Susil RC, et al. Int J Radiat Oncol Biol Phys. 2010 Mar 15;76(4):1251-8. Epub 2009 Nov 24